I would think zoning time would be one of the lesser concerns. I cannot run the game on Very High or Extreme Quality since RoK came out - I will shortly get a crash with a message that the game tried requesting more than 2GB of RAM. It is not an uncommon issue, as seen in the tech support forum.Take the game in that state of metastability and introduce areas that could be crammed to the gills with objects, some of which move and/or have particle effects. You might be able to do it if you run your graphics low enough, but then you are potentially missing out on some of the appearance that you are trying to display.
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