I have never hit a T6 named epic mob with Bare fists, however I can hit weaker wpic mobs bare fisted, such as the Epicx2 mobs in Clefts of Rujark. I have parsed many times, and my barehanded dps is significantly less than when duel wielding.... though I have about 7 different fabled weapons, including 2 Tier 6 Fabled duel wielders.